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KMID : 0359920100290040539
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Korean Journal of Nephrology
2010 Volume.29 No. 4 p.539 ~ p.543
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De Novo Light Chain Deposition Disease in Long-term Survived Renal Allograft
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Choe Mi-Sun
Jang Mi-Hyun
Hwang Eun-Ah
Lee Sang-Sook
Kim Hyun-Chul
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Abstract
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Light chain deposition disease (LCDD) is characterized by the deposition of abnormal immunoglobulin light chains in many organs, including kidney. It is usually associated with multiple myeloma or other lymphoproliferative disorders. Myeloma usually occurs in old age and may develop after renal transplantation thus being categorized as posttransplant lymphoproliferative disease (PTLD). Renal LCDD usually presents with variable degree of proteinuria and renal insufficiency. The diagnosis of LCDD depends on histologic findings with detection of monoclonal immunoglobulin light chain. Histologically, it is characterized by nodular glomerulosclerosis. We report the first case of de novo LCDD associated with myeloma after renal transplantation in Korea. With advancing renal transplantation and increasing old aged renal recipients, myeloma or LCDD should be included in the differential diagnoses of renal recipient patients with deteriorating renal function.
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KEYWORD
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Kidney, Transplantation, Immunoglobulin light chain, Myeloma
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